two.2]decane core and defining the geometry on the exocyclic double bond. The activation energies of formation from the vinyl-gold intermediates were being calculated and uncovered a silyl enol ether with the unprotected indole moiety as a suitable precursor to the Toste cyclization. This six-action synthesis didn't entail any nonstrategic redox ma
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We use cookies to improve your expertise with us. To learn more - be sure to refer to our privacy coverage."We verified that conolidine binds to the freshly discovered opioid receptor ACKR3, whilst displaying no affinity for the other 4 classical opioid receptors. By doing this, conolidine blocks ACKR3 and prevents it from trapping the By natural m
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